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KMID : 0381219790110010025
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Journal of RIMSK
1979 Volume.11 No. 1 p.25 ~ p.31
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Cardiovascular Responses to Intratracheal Administration of Vasopressors
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Abstract
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The increasingly successful use of vasopressors for the restoration of spontaneous circulation is reported, thus the delay in their administration results in an increased incidence of brain damage.
The importance of prompt intracardiac and intravenous administration of vasopressors during attempts at resuscitation has already been recognized. However, the intracardiac injection is often accomplished with difficulty and delay. For these reasons, many physicians sought to establish the relative effectiveness of various routes of drug administration, which might be utilized during cardiopulmonary resuscitation.
The very rapid absorption of fluid from lungs has been clearly established and the effects of absorption of drugs from the lungs have been frequently observed. Therefore, intratracheal administration of vasopressors was tested in man and experimental animals. Vasopressors used in experiments were epinephrine, ephedrine, and effortil. The results were as follows:
1. The effectiveness of incremental M.A.P. was greater with epinephrine than with both ephedrine and effortil, and the incremental degree of M.A.P. was 10% or more in animal and clinical experiments.
2. The order of effectiveness on rapidity in increasing pulse rate was epinephrine, effortil and ephedrine, however, the order of magnitude of increase of M.A.P. induced by these agents was epinephrine, ephedrine and effortil.
3. Above results indicate that epinephrine and effortil influence pulse rate more than M.A.P. whereas ephedrine influence M.A.P. more than pulse rate.
4. There was no significant differences among vasopressors tested with regard to their effects on the parameters measured in the present experiments.
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